Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

Carcinogenesis cannot be explained only by genetic alterations, but also involves
epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic …

Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …

Epidemiological and clinical studies have indicated that nut consumption could be a healthy
dietary strategy to prevent and treat type 2 diabetes (T2DM) and related cardiovascular …

Nitric oxide (NO) vascular signaling has long been considered an independent, self-
sufficient pathway. However, recent data indicate that the novel gaseous mediator, hydrogen …

As people age they become increasingly susceptible to chronic and extremely debilitating
brain diseases. The precise cause of the neuronal degeneration underlying these disorders …

Las acciones biológicas de la insulina se inician al activar su receptor de membrana, el cual
desencadena múltiples vías de señalización que median sus acciones biológicas. Debido a …

The quest for novel therapies to prevent bacterial infections and blood clots (thrombosis) is
of utmost importance in biomedical research due to the exponential growth in the cases of …