[PDF][PDF] Dynamic RNA modifications in gene expression regulation
Over 100 types of chemical modifications have been identified in cellular RNAs. While the
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …
5′ cap modification and the poly (A) tail of eukaryotic mRNA play key roles in regulation …
Notch signaling in development, tissue homeostasis, and disease
C Siebel, U Lendahl - Physiological reviews, 2017 - journals.physiology.org
Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014
QT Ostrom, H Gittleman, P Liao… - Neuro …, 2017 - academic.oup.com
Background CBTRUS is a unique professional research organization that focuses
exclusively on providing high quality statistical data on the population-based incidence of …
exclusively on providing high quality statistical data on the population-based incidence of …
[PDF][PDF] Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
Landscape of microsatellite instability across 39 cancer types
Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …
[PDF][PDF] Intertumoral heterogeneity within medulloblastoma subgroups
While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
INTRODUCTION Tumor fitness, evolution, and resistance to therapy are governed by
selection of malignant cells with specific genotypes, by expression programs related to …
selection of malignant cells with specific genotypes, by expression programs related to …
DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis
Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III …
[HTML][HTML] Glioma subclassifications and their clinical significance
R Chen, M Smith-Cohn, AL Cohen, H Colman - Neurotherapeutics, 2017 - Elsevier
The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …
[PDF][PDF] Integrative genomic analysis of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor
prognosis and limited treatment options. Here, we describe the integrated analysis of …
prognosis and limited treatment options. Here, we describe the integrated analysis of …