Recent advances in the realm of allosteric modulators for opioid receptors for future therapeutics
M Remesic, VJ Hruby, F Porreca… - ACS chemical …, 2017 - ACS Publications
Opioids, and more specifically μ-opioid receptor (MOR) agonists such as morphine, have
long been clinically used as therapeutics for severe pain states but often come with serious …
long been clinically used as therapeutics for severe pain states but often come with serious …
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4, 6-diaryl-3-cyano-4H-pyran core: Switch …
R Recio, E Vengut-Climent, B Mouillac, H Orcel… - European Journal of …, 2017 - Elsevier
Abstract A library of 5-arylthiosubstituted 2-amino-4, 6-diaryl-3-cyano-4H-pyrans has been
synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade …
synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade …
Azepinone-Constrained Amino Acids in Peptide and Peptidomimetic Design
S Ballet, K Guillemyn, O Van der Poorten, B Schurgers… - Peptidomimetics I, 2017 - Springer
Side chain topography of amino acids that are part of a peptide's pharmacophore represents
a crucial structural feature in peptidomimetic design. Constraining the side chain dihedral …
a crucial structural feature in peptidomimetic design. Constraining the side chain dihedral …
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4, 6-diaryl-3-cyano-4H-pyran core: Switch …
R Recio Jiménez, E Vengut-Climent, B Mouillac… - European Journal of …, 2017 - idus.us.es
A library of 5-arylthiosubstituted 2-amino-4, 6-diaryl-3-cyano-4H-pyrans has been
synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade …
synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade …