Background: MicroRNAs (miRNAs) are a family of short noncoding RNAs that play important
roles in posttranscriptional gene regulation. miRNAs inhibit target gene expression by …

Background Lithium is the mainstay of treatment for bipolar disorder, mania and an
augmentation therapy in patients with treatment resistant depression. It has a narrow …

This chapter summarizes the current knowledge about the pharmacokinetics of lithium in
humans. It covers the various marketed pharmaceutical forms and salts of lithium, as well as …

Lithium has a narrow therapeutic index and can consequently result in considerable toxicity
if levels are not monitored regularly. Among lithium's potential side effects are two types of …

Lityum bipolar bozukluk tedavisinde oldukça sık kullanılan ve en etkin ilaçtır. Lityum ilişkili
nefrojenik diyabetes insipitus, kronik tübülointerstisyel nefrit ve akut tübüler nekroz …

Lithium remains the gold-standard medication for bipolar disorder, with 30–40% of older
patients responding preferentially to its use. However, its use is limited by potential medical …

Long-term lithium therapy is known to cause renal dysfunction, including nephrogenic
diabetes insipidus (nDI) and chronic tubulointerstitial nephropathy, which may progress to …

Background: Primary polydipsia occurs without any central (vasopressin) deficit and/or
peripheral (nephrogenic) organic impairment-associated with schizophrenia/obsessive …