Breath analysis not only holds great potential for the development of new non-invasive
diagnostic methods, but also for the identification and follow up of drug levels in breath. This …

Background. Predictive performance of eleven published propofol pharmacokinetic models
was evaluated for long-duration propofol infusion in children. Methods. Twenty-one aged …

Background Electroencephalogram (EEG) waveforms vary widely among individuals, this
decreases the usefulness of BIS™ monitors for assessing the effects of propofol. Practically …

The objective of this study was to characterize the propofol-fentanyl interaction in Beagles
for four pharmacodynamic endpoints: apnea, response to mechanical ventilation …

Introduction Intravenous (iv) acetaminophen is administered during surgery for
postoperative analgesia. However, little information is available on the pharmacokinetics of …

For drug administration in anesthesia practice, the goal is to achieve a desired and stable
clinical effect, which requires accurate control of blood and brain drug concentrations. For …

The aim of pharmacokinetic–pharmacodynamic (PKPD) modelling is to be able to predict
the time course of clinical effect resulting from different drug administration regimens and to …

Mathematical models of physiological processes can be used in critical care and
anaesthesia to improve the understanding of disease processes and to guide treatment …

The purpose of target-controlled infusion (TCI) is to calculate the amount of drug, based on
published pharmacokinetic-pharmacodynamic models, required to achieve and maintain a …

一般に, 鎮静薬に対する感受性は個人差が大きく, 静脈内鎮静法において個々の症例の術中至適
投与量を事前に予想することは困難である. 過量投与では管理の安全性が損なわれる可能性があり …