Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Nonalcoholic fatty liver disease (NAFLD) is defined as the presence of hepatic fat
accumulation after the exclusion of other causes of hepatic steatosis, including other causes …

Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …

Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of
death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and …

Bile acids are signaling molecules that coordinately regulate metabolism and inflammation
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …

Hepatocellular carcinoma (HCC) is the third leading cause of worldwide cancer mortality.
HCC almost exclusively develops in patients with chronic liver disease, driven by a vicious …

The lifestyle factors of physical activity, sedentary behaviour, and diet are increasingly being
studied for their associations with cancer. Physical activity is inversely associated with and …

Background & Aims Magnetic resonance imaging (MRI) techniques and ultrasound-based
transient elastography (TE) can be used in noninvasive diagnosis of fibrosis and steatosis in …

Non-alcoholic fatty liver disease has emerged a major challenge because of it prevalence,
difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the …

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …