Diabetic neuropathies are the most prevalent chronic complications of diabetes. This
heterogeneous group of conditions affects different parts of the nervous system and presents …

Although pain is a widely known phenomenon and an important clinical symptom that
occurs in numerous diseases, its mechanisms are still barely understood. Owing to the …

Purpose Chemotherapy-induced peripheral neuropathy (CIPN) may persist after treatment
ends and may lead to functional decline and falls. This study compared objective and self …

Background The prevalence of neuropathic pain (NeP) has been estimated within specific
health conditions; however, there are no published data on its broad prevalence in the US …

Highlights•Neuroinflammation in limbic structures co-occurs in both chronic pain and opioid
dependence.•Major depressive disorder is associated with neuroinflammation.•Chronic pain …

Opioids are the gold standard for pharmacological treatment of neuropathic pain, but their
analgesic effects are unsatisfactory in part due to nerve injury–induced downregulation of …

It has been suggested that the lack of rodent behavioral assays that represent the
complexities of human pain contributes to the poor translational record of basic pain …

Managing of neuropathic pain remains clinically challenging because the existing
pharmacotherapies are either ineffective or non-specific. Therefore, developing novel …

Methods Male rats were randomized into 3 groups: CCI, CCI+ HBO and the control group
(SHAM). Mechanical allodynia was tested daily following CCI procedure. HBO rats were …

Chronic post-surgical pain (CPSP) is currently an inevitable surgical complication. Despite
the advances in surgical techniques and the development of new modalities for pain …