Ambient ionization mass spectrometry was developed as a sample preparation-free
alternative to traditional MS-based workflows. Desorption electrospray ionization (DESI)-MS …

Over the last decade mass spectrometry imaging (MSI) has been integrated in to many
areas of drug discovery and development. It can have significant impact in oncology drug …

A new, more robust sprayer for desorption electrospray ionization (DESI) mass spectrometry
imaging is presented. The main source of variability in DESI is thought to be the uncontrolled …

Chronic kidney disease (CKD) poses a serious threat to the quality of human life and health
with an increasing incidence worldwide. Renal fibrosis is closely related to CKD and …

Mass spectrometry imaging by use of continuous-flow liquid microjunction sampling at
discrete locations (array mode) has previously been demonstrated. In this Letter, we …

Ion suppression from the tissue matrix has a severe effect on the mass spectrometry imaging
(MSI) of drugs. This problem hinders further applications of MSI in preclinical drug research …

Background: Non-alcoholic fatty liver disease (NAFLD) is a global health issue. Dietary
methyl donor restriction is used to induce a NAFLD/non-alcoholic steatohepatitis (NASH) …

In quantitative mass spectrometry imaging (Q-MSI) experiments, one or more standards are
either deposited directly onto the sample or delivered to the sample via the extraction …

Matrix-assisted laser desorption/ionization (MALDI) is a soft ionization technique which can
be used in mass spectrometry to produce ions from biomolecules without inducing the …

Non-alcoholic fatty liver disease (NAFLD) is the predominant cause of chronic liver disease
in the developed world, with an estimated prevalence of between 20–68% 1. The …