Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people
around the world mostly in Central and South America. T. cruzi expresses a wide variety of …

In trypanosomatids, etiological agents of devastating diseases, replication is robust and
finely controlled to maintain genome stability and function in stressful environments …

Studies of Leishmania donovani have shown that both ornithine decarboxylase and
spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for …

Endosymbiotic relationships between eukaryotic and prokaryotic cells are common in
nature. Endosymbioses between two eukaryotes are also known; cyanobacterium-derived …

There are hundreds of Trypanosoma species that live in the blood and tissue spaces of their
vertebrate hosts. The vast majority of these do not have the ornate system of antigenic …

The genomic sequences of 20 Leishmania infantum isolates collected in northeastern Brazil
were compared with each other and with the available genomic sequences of 29 L …

Background Leishmania is a protozoan parasite that alternates its life cycle between the
sand-fly vector and the mammalian host. This alternation involves environmental changes …

Abstract Background Leishmaniasis and Chagas disease are life-threatening illnesses
caused by the protozoan parasites Leishmania spp. and Trypanosoma cruzi, respectively …

Leishmania are unicellular eukaryotes responsible for leishmaniasis in humans. Like other
trypanosomatids, leishmania regulate protein coding gene expression almost exclusively at …

There is an urgent need for the identification and validation of new therapeutic targets in
protozoan parasites because currently available drugs are limited in number and …