Brain energy metabolism spurns fatty acids as fuel due to their inherent mitotoxicity and potential capacity to unleash neurodegeneration
P Schönfeld, G Reiser - Neurochemistry international, 2017 - Elsevier
The brain uses long-chain fatty acids (LCFAs) to a negligible extent as fuel for the
mitochondrial energy generation, in contrast to other tissues that also demand high energy …
mitochondrial energy generation, in contrast to other tissues that also demand high energy …
[HTML][HTML] Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy
The activation of the highly conserved unfolded protein response (UPR) is prominent in the
pathogenesis of the most prevalent neurodegenerative disorders, such as Alzheimer's …
pathogenesis of the most prevalent neurodegenerative disorders, such as Alzheimer's …
[HTML][HTML] Paradoxical inhibition of glycolysis by pioglitazone opposes the mitochondriopathy caused by AIF deficiency
Mice with the hypomorphic AIF-Harlequin mutation exhibit a highly heterogeneous
mitochondriopathy that mostly affects respiratory chain complex I, causing a cerebral …
mitochondriopathy that mostly affects respiratory chain complex I, causing a cerebral …
Effects of functional CYP2C8, CYP2C9, CYP3A5, and ABCB1 genetic variants on the pharmacokinetics of insulin sensitizer pioglitazone in Chinese Han individuals
SJ Yin, HM Qi, X Wang, P Zhang, Y Lu… - Pharmacogenetics …, 2017 - journals.lww.com
Results The results confirmed that the unique frequencies of CYP2C8* 2 (0.0%), CYP2C8* 3
(0.0%), and CYP2C9* 2 (0.0%) alleles were significantly different from those reported in …
(0.0%), and CYP2C9* 2 (0.0%) alleles were significantly different from those reported in …
[PDF][PDF] Paradoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency
Manuel Schiff a, c, Guido Kroemer d, e, f, g, h, Massimo Zeviani i, Pierre Rustin a,⁎ a
INSERM UMR 1141, PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité …
INSERM UMR 1141, PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité …