Sensory perception in autism

CE Robertson, S Baron-Cohen - Nature Reviews Neuroscience, 2017 - nature.com
Autism is a complex neurodevelopmental condition, and little is known about its
neurobiology. Much of autism research has focused on the social, communication and …

The changing epidemiology of autism spectrum disorders

K Lyall, L Croen, J Daniels, MD Fallin… - Annual review of …, 2017 - annualreviews.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with lifelong
impacts. Genetic and environmental factors contribute to ASD etiology, which remains …

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Z Li, J Chen, H Yu, L He, Y Xu, D Zhang, Q Yi, C Li… - Nature …, 2017 - nature.com
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Concepts, estimation and interpretation of SNP-based heritability

J Yang, J Zeng, ME Goddard, NR Wray, PM Visscher - Nature genetics, 2017 - nature.com
Abstract Narrow-sense heritability (h 2) is an important genetic parameter that quantifies the
proportion of phenotypic variance in a trait attributable to the additive genetic variation …

Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa

L Duncan, Z Yilmaz, H Gaspar… - American journal of …, 2017 - Am Psychiatric Assoc
Objective: The authors conducted a genome-wide association study of anorexia nervosa
and calculated genetic correlations with a series of psychiatric, educational, and metabolic …

Autism genetics: opportunities and challenges for clinical translation

JAS Vorstman, JR Parr, D Moreno-De-Luca… - Nature Reviews …, 2017 - nature.com
Genetic studies have revealed the involvement of hundreds of gene variants in autism. Their
risk effects are highly variable, and they are frequently related to other conditions besides …

A hierarchical causal taxonomy of psychopathology across the life span.

BB Lahey, RF Krueger, PJ Rathouz… - Psychological …, 2017 - psycnet.apa.org
We propose a taxonomy of psychopathology based on patterns of shared causal influences
identified in a review of multivariate behavior genetic studies that distinguish genetic and …

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

DJ Weiner, EM Wigdor, S Ripke, RK Walters… - Nature …, 2017 - nature.com
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo
variation. We aimed to clarify the influence of polygenic risk for ASD and to identify …

Reevaluation of SNP heritability in complex human traits

D Speed, N Cai, Ucleb Consortium, MR Johnson… - Nature …, 2017 - nature.com
SNP heritability, the proportion of phenotypic variance explained by SNPs, has been
reported for many hundreds of traits. Its estimation requires strong prior assumptions about …

Dissecting the genetics of complex traits using summary association statistics

B Pasaniuc, AL Price - Nature reviews genetics, 2017 - nature.com
During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …