There is significant variation in the way individuals react and respond to extreme stress and
adversity. While some individuals develop psychiatric conditions such as posttraumatic …

There is an urgent need for more effective medications to treat major depressive disorder, as
fewer than half of depressed patients achieve full remission and many are not responsive …

Neuropathic pain is a complex chronic condition characterized by various sensory,
cognitive, and affective symptoms. A large percentage of patients with neuropathic pain are …

Current therapeutic options for major depressive disorder (MDD) and bipolar disorder (BD)
are associated with a lag of onset that can prolong distress and impairment for patients, and …

Histone deacetylases (HDACs) play a crucial role in the remodeling of chromatin, and are
involved in the epigenetic regulation of gene expression. In the last decade, inhibition of …

Stress-related disorders, such as anxiety, early life stress, and posttraumatic stress disorder
appear to be important factors in promoting alcoholism, as alcohol consumption can …

Early-life stress is a potent risk factor for development of psychiatric conditions such as
depression. The underlying mechanisms remain poorly understood. Here, we used the early …

Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their
effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic …

The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and
neuronal plasticity, is upregulated in Alzheimer's disease (AD) patients and mouse models …

Accumulating evidence suggests that histone hypoacetylation which is partly mediated by
histone deacetylase (HDAC), plays a causative role in the etiology of various clinical …