Discovery of a small-molecule bromodomain-containing protein 4 (BRD4) inhibitor that induces AMP-activated protein kinase-modulated autophagy-associated cell …

L Ouyang, L Zhang, J Liu, L Fu, D Yao… - Journal of medicinal …, 2017 - ACS Publications
Upon the basis of The Cancer Genome Atlas (TCGA) data set, we identified that several
autophagy-related proteins such as AMP-activated protein kinase (AMPK) were remarkably …

Design of small molecule autophagy modulators: a promising druggable strategy

S He, Q Li, X Jiang, X Lu, F Feng, W Qu… - Journal of medicinal …, 2017 - ACS Publications
Autophagy is a lysosome-dependent mechanism of intracellular degradation for maintaining
cellular homeostasis. Dysregulation of autophagy has been verified to be closely linked to a …