Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative, clinically
heterogeneous syndrome pathologically overlapping with frontotemporal dementia. To date …

Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease, with large
variation in survival between patients. Currently, it remains rather difficult to predict survival …

Objective Our objective was to study the hypothalamic volume in a cohort of patients with
amyotrophic lateral sclerosis (ALS) including symptomatic and presymptomatic ALS …

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease defined by
the presence of muscle weakness. The motor features of disease are heterogeneous in site …

Two nerve cells types, Betz cells in layer Vb of the primary motor neocortex and α-
motoneurons of the lower brainstem and spinal cord, become involved at the beginning of …

Background Diagnostic uncertainty in ALS has serious management implications and
delays recruitment into clinical trials. Emerging evidence of presymptomatic disease-burden …

We aimed to investigate structural changes in vivo in memory-related white matter tracts (ie,
perforant pathway zone [PPZ]; uncinate fasciculus [UF]; fornix) using diffusion tensor …

Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for
cerebral microstructural alterations in neurodegenerative diseases is under investigation. In …

Multiple Sclerosis (MS) pathology is complex and includes inflammatory processes,
neurodegeneration, and demyelination. While multiple drugs have been developed to tackle …

The pathological process underlying sporadic amyotrophic lateral sclerosis (sALS) that is
associated with the formation of cytoplasmic inclusions of a nuclear protein (TDP-43) is …