Diabetic neuropathies are the most prevalent chronic complications of diabetes. This
heterogeneous group of conditions affects different parts of the nervous system and presents …

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is
the leading cause of CKD worldwide. Although ESRD may be the most recognizable …

Background Intensive glucose control is understood to prevent complications in adults with
type 2 diabetes. We aimed to more precisely estimate the effects of more intensive glucose …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

ABSTRACT Abbreviations: A1C= hemoglobin A1C AACE= American Association of Clinical
Endocrinologists ACCORD= Action to Control Cardiovascular Risk in Diabetes ACCORD …

Peripheral neuropathy is a major cause of disability worldwide. Diabetes is the most
common cause of neuropathy, accounting for 50% of cases. Over half of people with …

Type 2 diabetic kidney disease (DKD) is the most common cause of CKD and ESRD
worldwide, and carries with it enormous human and societal costs. The goal of this review is …

Background Limited evidence suggests that multifactorial interventions for control of
glucose, blood pressure, and lipids reduce macrovascular complications and mortality in …

Abstract Background: Emapticap pegol (NOX-E36) is a Spiegelmer® that specifically binds
and inhibits the pro-inflammatory chemokine CC motif-ligand 2 (CCL2)(also called …