Purpose Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that
affects women of reproductive age and is characterized by ovulatory dysfunction and/or …

Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

Abstract Cosponsoring Associations: The European Society of Endocrinology and the
Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective …

In 1968, Bruce McEwen discovered that 3 H-corticosterone administered to
adrenalectomised rats is retained in neurons of hippocampus rather than those of …

The central link between obesity and type 2 diabetes is the development of insulin
resistance. To date, it is still not clear whether hyperinsulinemia causes insulin resistance …

Background Childhood obesity is a serious public health problem associated with the
development of several chronic diseases, such as type 2 diabetes mellitus, dyslipidemia …

Physical inactivity is a primary contributor to diseases such as obesity, cardiovascular
disease, and type 2 diabetes. Accelerometry data suggest that a majority of US adults fail to …

Abstract Objective Antipsychotics (APs) are associated with metabolic syndrome, with
increases in leptin proposed as an underlying mechanism of AP‐induced weight gain …

Context and aims Functional leptin deficiency is characterized by high levels of circulating
immunoreactive leptin (irLep), but a reduced bioactivity of the hormone due to defective …

Increasing prevalence of obesity and obesity-related conditions worldwide has necessitated
a more thorough understanding of adipose tissue (AT) and expanded the scope of research …