Allergic inflammation is a type 2 immune disorder classically characterized by high levels of
immunoglobulin E (IgE) and the development of Th2 cells. Asthma is a pulmonary allergic …

Summary Interleukin (IL)‐33 is a key cytokine involved in type 2 immunity and allergic
airway diseases. Abundantly expressed in lung epithelial cells, IL‐33 plays critical roles in …

Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate
pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to …

Eosinophils are innate immune cells that, under certain conditions, can be recruited to the
lungs, where they have an incompletely understood role in health and disease. Eosinophils …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents' survival, we …

IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and
has emerged as a promising new drug target for asthma and allergic disease. Common …

Malignant hematological diseases are mainly because of the occurrence of molecular
abnormalities leading to the deregulation of signaling pathways essential for precise cell …

Background Allergic airway inflammation is triggered by allergen exposure through several
steps including release of IL-33, which promotes cytokine (IL-5, IL-13) production by type 2 …

Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a
genome-wide association study of 19,219 individuals, we found 38 new variants and …

Allergic diseases are on the increase globally in parallel with a decrease in parasitic
infection. The inverse association between parasitic infections and allergy at an ecological …