The most common form of senile dementia is Alzheimer's disease (AD), which is
characterized by the extracellular deposition of amyloid β-peptide (Aβ) plaques and the …

Alzheimer's disease (AD), the most common neurodegenerative disorder, is the leading
cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology …

Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of
millions of people affected worldwide. The pathogenesis is still poorly understood and …

As a protease complex involved in the cleavage of amyloid precursor proteins that lead to
the formation of amyloid β fibrils implicated in Alzheimer's disease, γ-secretase is an …

Abstract γ-Secretase is an intramembrane aspartyl protease that cleaves the C99 fragment
of amyloid precursor protein to generate extracellular Aβ peptides. These peptides can …

The intensity and duration of TGF-β signaling determine the cellular biological response.
How this is negatively regulated is not well understood. Here, we identified a novel negative …

Some epidemiological studies suggest an inverse correlation between cancer incidence
and Alzheimer's disease (AD). In this study, we demonstrated experimental evidences for …

The presenilin proteins are the catalytic subunits of a tetrameric complex containing
presenilin 1 or 2, anterior pharynx defective 1 (APH1), nicastrin, and PEN-2. Other …

Background: β-Amyloid (Aβ) is the product of concerted cleavage of the amyloid precursor
protein (APP) by β-and γ-secretases. However, the molecular mechanisms that regulate this …

Weitere Personen waren an der inhaltlich-materiellen Erstellung der vorliegenden Arbeit
nicht beteiligt. Insbesondere habe ich nicht die entgeltliche Hilfe von Vermittlungs-bzw …