Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Puberty is a major developmental stage. Damaging mutations, considered as “mistakes of
nature”, have contributed to the unraveling of the networks implicated in the normal initiation …

Context: Central precocious puberty (CPP) results from premature activation of the
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …

Background/Aims: Recently, loss-of-function mutations in the MKRN3 gene have been
implicated in the etiology of familial central precocious puberty (CPP) in both sexes. We …

В книге рассматриваются современные взгляды о роли генетических, эндокринных и
иммунологических факторов в патогенезе генитального эндометриоза, обсуждаются …

To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as
suggested by recent in vitro studies, independently of confounders. 261 nondiabetic …

Background: Little is known about the genetic causes responsible for idiopathic central
precocious puberty (iCPP). More recently, described loss-of-function mutations in the …

The human genome encodes~ 750 G‐protein‐coupled receptors (GPCR s), including
prokineticin receptor 2 (PROKR 2) involved in the regulation of sexual maturation …

The timing of puberty onset varies greatly among individuals, and much of this variation is
modulated by genetic factors. This study aimed to identify the kisspeptin receptor (KISS1R) …

Central or gonadotropin-dependent precocious puberty (CPP) caused by early activation of
pulsatile Gonadotropinreleasing hormone (GnRH) secretion is clinically defined by the early …