Shaping proteostasis at the cellular, tissue, and organismal level
The proteostasis network (PN) regulates protein synthesis, folding, transport, and
degradation to maintain proteome integrity and limit the accumulation of protein aggregates …
degradation to maintain proteome integrity and limit the accumulation of protein aggregates …
The role of co-chaperones in synaptic proteostasis and neurodegenerative disease
EL Gorenberg, SS Chandra - Frontiers in neuroscience, 2017 - frontiersin.org
Synapses must be preserved throughout an organism's lifespan to allow for normal brain
function and behavior. Synapse maintenance is challenging given the long distances …
function and behavior. Synapse maintenance is challenging given the long distances …
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
Amyotrophic lateral sclerosis (ALS) is a heterogeneous degenerative motor neuron disease
linked to numerous genetic mutations in apparently unrelated proteins. These proteins …
linked to numerous genetic mutations in apparently unrelated proteins. These proteins …
Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
P Wang, CM Wander, CX Yuan, MS Bereman… - Nature …, 2017 - nature.com
TDP-43 pathology marks a spectrum of multisystem proteinopathies including amyotrophic
lateral sclerosis, frontotemporal lobar degeneration, and sporadic inclusion body myositis …
lateral sclerosis, frontotemporal lobar degeneration, and sporadic inclusion body myositis …
The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
Protein inclusions are a predominant molecular pathology found in numerous
neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington's …
neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington's …
Molecular chaperone accumulation in cancer and decrease in Alzheimer's disease: the potential roles of HSF1
SK Calderwood, A Murshid - Frontiers in Neuroscience, 2017 - frontiersin.org
Molecular chaperones are required to maintain the proteome in a folded and functional
state. When challenges to intracellular folding occur, the heat shock response is triggered …
state. When challenges to intracellular folding occur, the heat shock response is triggered …
Clusterin protects neurons against intracellular proteotoxicity
It is now widely accepted in the field that the normally secreted chaperone clusterin is
redirected to the cytosol during endoplasmic reticulum (ER) stress, although the …
redirected to the cytosol during endoplasmic reticulum (ER) stress, although the …
Cellular chaperones as therapeutic targets in ALS to restore protein homeostasis and improve cellular function
B Kalmar, L Greensmith - Frontiers in Molecular Neuroscience, 2017 - frontiersin.org
Heat shock proteins (Hsps) are ubiquitously expressed chaperone proteins that enable cells
to cope with environmental stresses that cause misfolding and denaturation of proteins. With …
to cope with environmental stresses that cause misfolding and denaturation of proteins. With …
Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins
Although it is well known that astrocytes are less vulnerable than neurons in
neurodegenerative diseases, the mechanism behind this differential vulnerability is unclear …
neurodegenerative diseases, the mechanism behind this differential vulnerability is unclear …
A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated …
B Wang, Y Liu, L Huang, J Chen, JJ Li, R Wang… - Molecular …, 2017 - nature.com
Induction of neuroprotective heat-shock proteins via pharmacological Hsp90 inhibitors is
currently being investigated as a potential treatment for neurodegenerative diseases. Two …
currently being investigated as a potential treatment for neurodegenerative diseases. Two …