Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …

Increased glomerular capillary pressure (glomerular hypertension) and increased
glomerular filtration rate (glomerular hyperfiltration) have been proven to cause …

Progressive kidney diseases are often associated with scarring of the kidney's filtration unit,
a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of …

The efficacy of B cell depletion therapies in diseases such as nephrotic syndrome and
rheumatoid arthritis suggests a broader role in B cells in human disease than previously …

Podocytes form the outer part of the glomerular filter, where they have to withstand
enormous transcapillary filtration forces driving glomerular filtration. Detachment of …

Hyper-activation of Rac1, a small GTPase, in glomerular podocytes has been implicated in
the pathogenesis of familial proteinuric kidney diseases. However, the role of Rac1 in …

Tyrosine and serine/threonine signal-transduction pathways influence many aspects of cell
behavior, including the spatial and temporal regulation of the actin cytoskeleton. However …

Progressive fibrosis of the interstitium is the dominant final pathway in renal destruction in
native and transplanted kidneys. Over time, the continuum of molecular events following …

Podocytes, the postmitotic and highly branched epithelial cells of the glomerulus, play a
pivotal role for the function of the glomerular filtration barrier and the development of chronic …

Background and Purpose Therapeutic options for treating glomerulopathies, the main cause
of chronic kidney disease, are limited. Podocyte dedifferentiation is a major event in the …