HVEM imprints memory potential on effector CD8 T cells required for protective mucosal immunity
Mucosal immunity to reinfection with a highly virulent virus requires the accumulation and
persistence of memory CD8 T cells at the site of primary infection. These cells may derive …
persistence of memory CD8 T cells at the site of primary infection. These cells may derive …
Deletion of the K1L Gene Results in a Vaccinia Virus That Is Less Pathogenic Due to Muted Innate Immune Responses, yet Still Elicits Protective Immunity
AG Bravo Cruz, A Han, EJ Roy, AB Guzmán… - Journal of …, 2017 - Am Soc Microbiol
All viruses strategically alter the antiviral immune response to their benefit. The vaccinia
virus (VACV) K1 protein has multiple immunomodulatory effects in tissue culture models of …
virus (VACV) K1 protein has multiple immunomodulatory effects in tissue culture models of …
Antigen exposure history defines CD8 T cell dynamics and protection during localized pulmonary infections
N Van Braeckel-Budimir, MD Martin… - Frontiers in …, 2017 - frontiersin.org
Unlike systemic infections, little is known about the role of repeated localized infections on
(re) shaping pathogen-specific memory CD8 T cell responses. Here, we used primary (1°) …
(re) shaping pathogen-specific memory CD8 T cell responses. Here, we used primary (1°) …