Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Chromosomal aberrations during cell division represent one of the first recognized features
of human cancer cells, and modern detection methods have revealed the pervasiveness of …

Error-free chromosome segregation is essential for the maintenance of genomic integrity
during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger …

Cancer cells often display chromosomal instability (CIN), a defect that involves loss or
rearrangement of the cell's genetic material–chromosomes–during cell division. This …

Cancer is a devastating disease that claims over 8 million lives each year. Understanding
the molecular etiology of the disease is critical to identify and develop new therapeutic …

DNA double-strand breaks (DSBs) prevent cells from entering mitosis allowing cells to repair
their genomic damage. Little is known about the response to DSBs once cells have already …

Aneuploidy, the state of having gained or lost chromosomes, is a hallmark of cancer.
Approximately 90% of tumors have gained or lost at least one chromosome. In spite of …

Chromosomal instability is a hallmark of cancer and correlates with the presence of extra
centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead …

Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour
constitutes the basis for many biological processes such as cellular motility, cytoplasmic …

Inhibition of the microtubule (MT) motor protein Eg5 results in a mitotic arrest due to the
formation of monopolar spindles, making Eg5 an attractive target for anti-cancer therapies …