Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Female mice are less susceptible to the negative metabolic consequences of high-fat diet
feeding than male mice, for reasons that are incompletely understood. Here we identify sex …

Abstract CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of
chemokines which is unique and combines the properties of both chemoattractant and …

Abstract Background Histone deacetylase inhibitor (HDACi), sodium butyrate (SB), has been
shown to be neuroprotective in adult brain injury models. Potential explanation for the …

Self-preservation is required for life. At the cellular level, this fundamental principle is
expressed in the form of molecular mechanisms for preconditioning and tolerance. When the …

Early recruitment of non-classical monocytes and their macrophage derivatives is
associated with augmented tissue repair and improved integration of biomaterial constructs …

Radiotherapy is an effective tool in the treatment of malignant brain tumors. However,
damage to brain stem and progenitor cells constitutes a major problem and is associated …

The hippocampus is negatively affected by aging and neurodegenerative diseases leading
to impaired learning and memory abilities. A diverse series of progressive modifications in …

CX3CL1 is a chemokine for which neurons constitute its primary source within the brain.
Besides acting as a chemokine, CX3CL1 regulates multiple processes and is known to …