Thirty years ago, Robert F. Furchgott concluded that nitric oxide, a compound traditionally
known to be a toxic component of fuel exhaust, is in fact released from the endothelium, and …

Diabetic retinopathy is the leading cause of blindness in the working age population.
Unfortunately, there is no cure for this devastating ocular complication. The early stage of …

We investigated the role of connexin 43 (Cx43) in maintaining the integrity of mitochondria in
brown adipose tissue (BAT). The functional effects of Cx43 were evaluated using inducible …

Nrf2/ARE signaling pathway is a crucial cellular defense system to cope with oxidative
stress, which is adaptively activated, in diabetic condition that is not efficient enough to resist …

In diabetic retinopathy, high glucose (HG)-mediated breakdown in cell-cell communication
promotes disruption of retinal homeostasis. Several studies indicate that HG condition alters …

Glioblastoma (GBM) is the most malignant primary brain tumor, with an average survival rate
of 15 months. GBM is highly refractory to therapy, and such unresponsiveness is due …

Objective To characterize clinical features and identify genetic causes of a patient with
oculodentodigital dysplasia (ODDD). Subjects and methods Clinical, dental, radiological …

Folliculostellate cell gap junctions establish a network for the transmission of information
within the anterior pituitary. Connexins make up gap junction channels. Changes in …

Gap junction (GJ) channels facilitate cell–cell communication through the exchange of
chemical and mechanical signals, ensuring proper tissue development and homeostasis …

We analyze a one-dimensional PDE-ODE system representing the diffusion of signaling
molecules between two cells coupled by a stochastically gated gap junction. We assume …