Aminoglycosides and the anticancer drug cisplatin can cause permanent hearing loss,
which impacts patients' quality of life and results in considerable subsequent costs. Since …

Thiopurine‐related hematotoxicity in pediatric acute lymphoblastic leukemia (ALL) and
inflammatory bowel diseases has been linked to genetically defined variability in thiopurine …

Approximately 25% of hereditary breast cancer cases are associated with a strong familial
history which can be explained by mutations in BRCA1 or BRCA2 and other lower …

The scale and scope of pharmacogenomics research continues to expand as the cost and
efficiency of molecular data generation techniques advance. These new technologies give …

Background Ototoxicity is a common adverse side effect of platinum chemotherapy and
cranial radiation therapy; however, individual susceptibility is highly variable. Therefore, our …

Genome-wide association studies (GWAS) allow the finding of genetic variants associated
with several traits. Regarding ovarian cancer (OC), 15 GWAS have been conducted since …

随着药物基因组学研究的不断发展, 医学大数据在药物基因组学领域中的应用越来越多.
本文从建立大型药物基因组学数据库, 借助电子健康档案与基因分型数据库开展药物基因组学 …

在全基因组关联分析(GWAS) 时代发现的大量药物应答相关位点位于非编码序列,
对其机制解释多关注于这些位点对mRNA 表达水平的影响. 表达数量性状位点(expression …

Objective: To examine germline single nucleotide polymorphisms (SNPs) as markers of
response to gemcitabine platinum (GP) combination chemotherapy in urothelial carcinoma …

Durante esta etapa da minha vida académica que agora termina, tive a oportunidade de
alargar os meus conhecimentos numa área de eleição, assim como de crescer a nível …