Molecular pharmacology of phytocannabinoids
SE Turner, CM Williams, L Iversen… - … : unraveling the complex …, 2017 - Springer
Cannabis sativa has been used for recreational, therapeutic and other uses for thousands of
years. The plant contains more than 120 C 21 terpenophenolic constituents named …
years. The plant contains more than 120 C 21 terpenophenolic constituents named …
Cannabinoid CB1 and CB2 Receptor Signaling and Bias
An agonist that acts through a single receptor can activate numerous signaling pathways.
Recent studies have suggested that different ligands can differentially activate these …
Recent studies have suggested that different ligands can differentially activate these …
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
M Soethoudt, U Grether, J Fingerle, TW Grim… - Nature …, 2017 - nature.com
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various
forms of tissue injury and inflammatory diseases. Although numerous compounds have …
forms of tissue injury and inflammatory diseases. Although numerous compounds have …
Cannabinoid signaling in health and disease
Y Lu, HD Anderson - Canadian journal of physiology and …, 2017 - cdnsciencepub.com
Cannabis sativa has long been used for medicinal purposes. To improve safety and efficacy,
compounds from C. sativa were purified or synthesized and named under an umbrella group …
compounds from C. sativa were purified or synthesized and named under an umbrella group …
Cannabis: a treasure trove or pandora's box?
K Solymosi, A Köfalvi - Mini reviews in medicinal chemistry, 2017 - ingentaconnect.com
Background & Objective: Cannabis is one of the earliest cultivated plants. Cannabis of
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …
Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets
S Mallipeddi, DR Janero, N Zvonok… - Biochemical …, 2017 - Elsevier
The phenomenon of functional selectivity, whereby a ligand preferentially directs the
information output of a G-protein coupled receptor (GPCR) along (a) particular effector …
information output of a G-protein coupled receptor (GPCR) along (a) particular effector …
Cannabinoid receptor ligand bias: implications in the central nervous system
RB Laprairie, AM Bagher… - Current opinion in …, 2017 - Elsevier
Highlights•Cannabinoid receptors are pleiotropically-coupled GPCRs.•Few studies quantify
cannabinoid bias using Black and Leff's operational model.•Correlations between …
cannabinoid bias using Black and Leff's operational model.•Correlations between …
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity …
F Spinelli, E Capparelli, C Abate… - Journal of Medicinal …, 2017 - ACS Publications
Up-regulation of CB2R on activated microglial cells, the first step in neurodegeneration, has
been widely demonstrated, and this finding makes the receptor a promising target in the …
been widely demonstrated, and this finding makes the receptor a promising target in the …
The central cannabinoid receptor type-2 (CB2) and chronic pain
Y Shang, Y Tang - International Journal of Neuroscience, 2017 - Taylor & Francis
ABSTRACT Cannabinoid receptor type-2 (CB2, CB2 receptor or CB2-R) mediates analgesia
via two mechanisms. CB2 receptors contained in peripheral immune tissue mediate …
via two mechanisms. CB2 receptors contained in peripheral immune tissue mediate …
Seeing through the smoke: human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks
Public opinion surrounding the recreational use and therapeutic potential of cannabis is
shifting. This review describes new work examining the behavioural and neural effects of …
shifting. This review describes new work examining the behavioural and neural effects of …