T follicular helper (Tfh) cells are a subset of CD4+ T cells that promote antibody production
during vaccination. Conventional dendritic cells (cDCs) efficiently prime Tfh cells; however …

Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues,
such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from …

Asthma is a common chronic lung disease that affects 300 million people worldwide. It
causes the airways of the lungs to swell and narrow due to inflammation (swelling and …

Plasma cell differentiation is a tightly regulated process that requires appropriate T cell helps
to reach the induction threshold. To further understand mechanisms by which T cell inputs …

CD4+ follicular helper T (Tfh) cells have been shown to be critical for the activation of
germinal center (GC) B-cell responses. Similar to other infections, Plasmodium infection …

To reconcile conflicting reports on the role of CD40 signaling in germinal center (GC)
formation, we examined the earliest stages of murine GC B cell differentiation. Peri-follicular …

T cell–dependent germinal center (GC) responses require coordinated interactions of T cells
with two antigen-presenting cell (APC) populations, B cells and dendritic cells (DCs), in the …

An aberrant immune response has been implicated in the pathogenesis of osteoarthritis
(OA). However, the role of peripheral blood follicular helper T (TFH) cells in the …

The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes
cell death or anergy is supported by in vivo studies of B cells that are continuously exposed …

High-affinity antibody production through the germinal centre (GC) response is a pivotal
process in adaptive immunity. Abnormal development of follicular helper T (TFH) cells can …