The cancer stem-like cell (CSC) hypothesis postulates that a small population of cells in a
cancer has self-renewal and clonal tumor initiation properties. These cells are responsible …

Purpose This study aims to determine the expression of miR-34b-5p in thyroid carcinomas
and to investigate the role of miR34b-5p in the modulation of proteins involved in …

Papillary thyroid carcinoma is the most frequent histologic type of thyroid tumor. Few studies
investigated the role of c-KIT expression in thyroid tumors, suggesting a role for this receptor …

Characterized by dysfunction of tissues, organs, organ systems and the whole organism,
aging results from the reduced function of effective stem cell populations. Recent advances …

Aims The Notch signalling pathway is involved in normal development as well as
tumorigenesis. However, it is unclear whether Notch activation is related to diverse …

Cachexia is associated with increased morbidity and mortality in cancer. The White adipose
tissue (WAT) synthesizes and releases several pro-inflammatory cytokines that play a role in …

Papillary thyroid cancer (PTC) is one of the endocrine cancers with high clinical and genetic
heterogeneity. NOTCH signaling and its downstream NOTCH-Regulated Ankyrin Repeat …

No effective strategy other than surgery can treat medullary thyroid carcinoma (MTC).
Notch1 expression can induce apoptosis of MTC cells. This study aimed to investigate the …

O câncer de tiroide é um relevante problema de saúde pública por ser o tumor maligno mais
comum do sistema endócrino. Para a obtenção de melhores tratamentos, estratégias …

Thyroid cancer is the most rampant endocrine malignancy accounting for> 80% of endocrine
malignancy and 1.8% of all recently distinguished cancer reports. The most important risk …