Cancer nanomedicine: progress, challenges and opportunities
J Shi, PW Kantoff, R Wooster, OC Farokhzad - Nature reviews cancer, 2017 - nature.com
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …
application of various nanotechnologies for more effective and safer cancer treatment …
Advances in the delivery of RNA therapeutics: from concept to clinical reality
The rapid expansion of the available genomic data continues to greatly impact biomedical
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a
category of versatile drug delivery systems that have been used in the biomedical field for> …
category of versatile drug delivery systems that have been used in the biomedical field for> …
[HTML][HTML] Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases
The gut microbiome plays a central role in inflammatory bowel diseases (IBDs)
pathogenesis and propagation. To determine whether the gut microbiome may predict …
pathogenesis and propagation. To determine whether the gut microbiome may predict …
Engineering and physical sciences in oncology: challenges and opportunities
The principles of engineering and physics have been applied to oncology for nearly 50
years. Engineers and physical scientists have made contributions to all aspects of cancer …
years. Engineers and physical scientists have made contributions to all aspects of cancer …
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
JE Dahlman, KJ Kauffman, Y Xing… - Proceedings of the …, 2017 - National Acad Sciences
Nucleic acid therapeutics are limited by inefficient delivery to target tissues and cells and by
an incomplete understanding of how nanoparticle structure affects biodistribution to off …
an incomplete understanding of how nanoparticle structure affects biodistribution to off …
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization
RL Ball, P Bajaj, KA Whitehead - International journal of …, 2017 - Taylor & Francis
The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded
delivery systems that maintain stability and potency for long times under ambient conditions …
delivery systems that maintain stability and potency for long times under ambient conditions …
Terminally modified RNA
T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as
tumors rapidly develop resistance to these agents. Here, we have uncovered an …
tumors rapidly develop resistance to these agents. Here, we have uncovered an …
Leveraging physiology for precision drug delivery
Physiological characteristics of diseases bring about both challenges and opportunities for
targeted drug delivery. Various drug delivery platforms have been devised ranging from …
targeted drug delivery. Various drug delivery platforms have been devised ranging from …