Cancer nanomedicine: progress, challenges and opportunities

J Shi, PW Kantoff, R Wooster, OC Farokhzad - Nature reviews cancer, 2017 - nature.com
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …

Advances in the delivery of RNA therapeutics: from concept to clinical reality

JC Kaczmarek, PS Kowalski, DG Anderson - Genome medicine, 2017 - Springer
The rapid expansion of the available genomic data continues to greatly impact biomedical
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …

Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

C Tapeinos, M Battaglini, G Ciofani - Journal of Controlled Release, 2017 - Elsevier
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a
category of versatile drug delivery systems that have been used in the biomedical field for> …

[HTML][HTML] Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases

AN Ananthakrishnan, C Luo, V Yajnik, H Khalili… - Cell host & …, 2017 - cell.com
The gut microbiome plays a central role in inflammatory bowel diseases (IBDs)
pathogenesis and propagation. To determine whether the gut microbiome may predict …

Engineering and physical sciences in oncology: challenges and opportunities

MJ Mitchell, RK Jain, R Langer - Nature Reviews Cancer, 2017 - nature.com
The principles of engineering and physics have been applied to oncology for nearly 50
years. Engineers and physical scientists have made contributions to all aspects of cancer …

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics

JE Dahlman, KJ Kauffman, Y Xing… - Proceedings of the …, 2017 - National Acad Sciences
Nucleic acid therapeutics are limited by inefficient delivery to target tissues and cells and by
an incomplete understanding of how nanoparticle structure affects biodistribution to off …

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

RL Ball, P Bajaj, KA Whitehead - International journal of …, 2017 - Taylor & Francis
The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded
delivery systems that maintain stability and potency for long times under ambient conditions …

Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy

K Jung, T Heishi, OF Khan, PS Kowalski… - The Journal of …, 2017 - Am Soc Clin Investig
Current anti-VEGF therapies for colorectal cancer (CRC) provide limited survival benefit, as
tumors rapidly develop resistance to these agents. Here, we have uncovered an …

Leveraging physiology for precision drug delivery

W Sun, Q Hu, W Ji, G Wright, Z Gu - Physiological reviews, 2017 - journals.physiology.org
Physiological characteristics of diseases bring about both challenges and opportunities for
targeted drug delivery. Various drug delivery platforms have been devised ranging from …