High-grade meningiomas frequently recur and are associated with high rates of morbidity
and mortality. To determine the factors that promote the development and evolution of these …

Objectives The clinical management of meningioma is guided by tumor grade and biological
behavior. Currently, the assessment of tumor grade follows surgical resection and …

Background. Meningiomas are the most common primary intracranial tumors in adults.
Identification of SMO and AKT1 mutations in meningiomas has raised the hope for targeted …

Meningiomas, derived from arachnoid cap cells, are the most common intracranial tumor.
High-grade meningiomas, as well as those located at the skull base or near venous sinuses …

Background Although meningioma is a common disease, there is a lack of understanding of
the underlying molecular mechanisms behind its initiation and progression. We used …

Postreplicative mismatch repair safeguards the stability of our genome. The defects in its
functioning will give rise to microsatellite instability. In this study, 50 meningiomas were …

Background: The aim of this study was to determine the cerebrospinal fluid (CSF) and serum
levels of EGF containing fibulin-like extracellular matrix protein 1 (EFEMP1) in the patients …

Abstract Purpose of Review Genomic profiling has led to a transformation in our
understanding, and clinical management, of many tumors of the central nervous system …

Structural variants (SV) are a heterogeneous class of genomic variation that can have
profound effects on the structure and function of the cancer genome. SVs are challenging to …

Meningiomas, tumors arising from the arachnoid cap cells that surround the brain, are the
most common primary tumor of the central nervous system. 1 The majority of meningiomas …