Repair-resistant DNA lesions
NE Geacintov, S Broyde - Chemical research in toxicology, 2017 - ACS Publications
The eukaryotic global genomic nucleotide excision repair (GG-NER) pathway is the major
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung
PW Villalta, JB Hochalter, SS Hecht - Analytical chemistry, 2017 - ACS Publications
Benzo [a] pyrene (BaP), an archetypical polycyclic aromatic hydrocarbon, is classified as
“carcinogenic to humans” and is ubiquitous in the environment, as evident by the …
“carcinogenic to humans” and is ubiquitous in the environment, as evident by the …
Data-independent mass spectrometry approach for screening and identification of DNA adducts
J Guo, PW Villalta, RJ Turesky - Analytical chemistry, 2017 - ACS Publications
Long-term exposures to environmental toxicants and endogenous electrophiles are
causative factors for human diseases including cancer. DNA adducts reflect the internal …
causative factors for human diseases including cancer. DNA adducts reflect the internal …
Liquid chromatography-tandem mass spectrometry for the quantification of tobacco-specific nitrosamine-induced DNA adducts in mammalian cells
Quantification of DNA lesions constitutes one of the main tasks in toxicology and in
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan
Abstract Background Heterocyclic aromatic amines (HAAs) may confer prostate cancer risk;
however, the evidence is inconclusive and the activity of HAA-metabolizing enzymes is …
however, the evidence is inconclusive and the activity of HAA-metabolizing enzymes is …
A rapid throughput method to extract DNA from formalin-fixed paraffin-embedded tissues for biomonitoring carcinogenic DNA adducts
Formalin-fixed paraffin-embedded (FFPE) tissues are rarely used for screening DNA
adducts of carcinogens because the harsh conditions required to reverse the formaldehyde …
adducts of carcinogens because the harsh conditions required to reverse the formaldehyde …