Over the last decade mass spectrometry imaging (MSI) has been integrated in to many
areas of drug discovery and development. It can have significant impact in oncology drug …

Cholesterolomics can be regarded as the identification and quantification of cholesterol, its
precursors post squalene, and metabolites of cholesterol and of its precursors, in a …

Corticosteroids influence the development and function of the heart and its response to
injury and pressure overload via actions on glucocorticoid (GR) and mineralocorticoid (MR) …

Multifunctional upconversion nanoparticles (UCNPs) that can be implemented in theranostic
applications are particularly attractive scaffolds for precise drug delivery. However, most of …

In the last decade, imaging mass spectrometry (IMS) has been the primary tool for
biomolecular imaging. While it is possible to map a wide range of biomolecules using matrix …

Sterolomics can be thought of as the quantitative determination of the entire complement of
molecules based on the cyclopentanoperhydrophenanthrene skeleton in a system. Mass …

Масс-спектрометрия (МС) в настоящее время служит мощным методом анализа и
исследования веществ. Развитие методологии, инструментальной базы и способов …

While analysis of the genome or proteome can be predictive of the fate of an organism, its
metabolome is informative of the outcome of events on an organism. The metabolome can …

ABSTRACT 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1; EC 1.1. 1.146) generates
active glucocorticoid hormones. Small molecule inhibitors have been developed to target …

Historically, studies of drug biodistribution are traditionally carried out in the later stages of
pre-clinical pharmaceutical research and development (R&D) using radio-labelled …