Dynamic changes in the expression of transcription factors (TFs) can influence the
specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs …

Differentiation and fate of virus-specific CD8+ T cells after cessation of chronic antigen
stimulation is unclear. Here we show that a TCF1+ CD127+ PD1+ hepatitis C virus (HCV) …

In response to acute viral infection, activated naive T cells give rise to effector T cells that
clear the pathogen and memory T cells that persist long-term and provide heightened …

Epigenetic mechanisms play a critical role during differentiation of T cells by contributing to
the formation of stable and heritable transcriptional patterns. To better understand the …

Transcription factors and DNA/histone modification enzymes work in concert to establish
and maintain cell identity. CD4+ and CD8+ T cells are key players in cellular immunity with …

Autoimmune lymphoproliferative syndrome (ALPS) is an incurable disease, which is
characterized by non‐malignant autoimmune lymphoproliferation. TCF 1 is a key effector in …

Abstract CD4+ and CD8+ T cells are critical components of the adaptive arm of immune
responses. During viral infection, CD8+ T cells utilize their cytotoxic function to kill infected …

During the immune response, naïve T cells are activated to produce a multitude of lineages
with distinct effector and memory functions. Effector T cells mediate an efficient adaptive …