Cell therapeutic approaches to treat a range of congenital and degenerative neuropathies
are under intense investigation. There have been recent significant advancements in the …

Background & Aims Cell therapy offers the potential to treat gastrointestinal motility disorders
caused by diseased or absent enteric neurons. We examined whether neurons generated …

Background: Enteric neural stem/progenitor cells (ENSCs) offer an innovative approach to
treating Hirschsprung disease (HSCR) and other enteric neuropathies. However, postnatal …

As current options for treating most enteric neuropathies are either non‐effective or
associated with significant ongoing problems, cell therapy is a potential attractive possibility …

The RET proto-oncogene was identified as a major locus involved in Hirschsprung disease
(HSCR). A genome-wide association study (GWAS) and whole exome sequencing identified …

In this study, we propose a novel method for inducing neuronal cells by briefly exposing
them to small‐molecule cocktails in a step‐by‐step manner. Global gene expression …

Disorders of the gastrointestinal tract make up some of the most common illnesses
experienced across the lifespan affecting individuals in infancy, childhood and adulthood …

Cell therapeutic approaches to treat a range of congenital and degenerative neuropathies
are under 16 intense investigation. There have been recent significant advancements in the …

Hirschsprungs disease (HD, HSCR) is a congenital aganglionosis of the distal gut with
variable extend. The pathogenic development of HD is caused by disturbance of cell …

Zusammenfassung Der Morbus Hirschsprung (MH) ist eine kongenitale Aganglionose, die
die distalen Darmabschnitte in variabler Ausdehnung ab ano betrifft. Die pathogenetische …