The transport of suspensions of microparticles in confined environments is associated with
complex phenomena at the interface of fluid mechanics and soft matter. Indeed, the …

Cell membranes are vital to shield a cell's interior from the environment. At the same time
they determine to a large extent the cell's mechanical resistance to external forces. In recent …

Three-dimensional (3D) in vitro models capturing both the structural and dynamic complexity
of the in vivo situation are in great demand as an alternative to animal models. Despite …

We present a computational methodology for modeling cellular-scale blood flow in arbitrary
and highly complex geometry. Our approach is based on immersed-boundary methods …

Many of the intriguing properties of blood originate from its cellular nature. Therefore,
accurate modeling of blood flow related phenomena requires a description of the dynamics …

We present, to our knowledge, the first direct numerical simulation of 3D cellular-scale blood
flow in physiologically realistic microvascular networks. The vascular networks are designed …

Pressure ulcers are a significant problem in health care, due to high costs and large impact
on patients' life. In general, pressure ulcers develop as tissue viability decreases due to …

Therapeutic embolotherapy is the deliberate occlusion of a blood vessel within the body,
which can be for the prevention of internal bleeding, stemming of flow through an …

Tumor cell invasion, whether penetrating through the extracellular matrix (ECM) or crossing
a vascular endothelium, is a critical step in the cancer metastatic cascade. Along the way …

We review recent advances in multiscale modeling of the biomechanical characteristics of
red blood cells (RBCs) in hematological diseases, and their relevance to the structure and …