Mental illness, including depression, anxiety and bipolar disorder, accounts for a significant
proportion of global disability and poses a substantial social, economic and heath burden …

Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated
epidemiological studies have demonstrated that BD has high rates of inflammatory medical …

Background The possible therapeutic impact of dietary changes on existing mental illness is
largely unknown. Using a randomised controlled trial design, we aimed to investigate the …

Background: Major depressive disorder is a common, chronic condition that imposes a
substantial burden of disability globally. As current treatments are estimated to address only …

The nascent field of 'Nutritional Psychiatry'offers much promise for addressing the large
disease burden associated with mental disorders. A consistent evidence base from the …

Objectives The first drug repurposed for the treatment of depression was the tuberculostatic
iproniazid. At present, drugs belonging to new classes of antidepressants still have …

There is a growing awareness that gut commensal metabolites play a major role in host
physiology and indeed the pathophysiology of several illnesses. The composition of the …

The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …

Abstract Major Depressive Disorder (MDD) is common among cancer patients, with
prevalence rates up to four-times higher than the general population. Depression confers …

This review examines the shared immune-inflammatory, oxidative and nitrosative stress
(IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder …