Paralog genes arise from gene duplication events during evolution, which often lead to
similar proteins that cooperate in common pathways and in protein complexes …

Genes are not randomly distributed in the genome. In humans, 10% of protein‐coding genes
are transcribed from bidirectional promoters and many more are organised in larger clusters …

Gene order is not random in eukaryotic chromosomes, and co-regulated genes tend to be
clustered. The mechanisms that determine co-regulation of large regions of the genome and …

Eukaryotic genomes frequently exhibit interdependency between transcriptional units, as
evidenced by regions of high gene density. It is well recognized that vertebrate microRNAs …

Although many diseases have been well characterized at the molecular level, the underlying
mechanisms often remain unclear. This may be attributed to the large number of genes for …