One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

During immune challenge, T lymphocytes engage pathways of anabolic metabolism to
support clonal expansion and the development of effector functions. Here we report a critical …

Cells require one-carbon units for nucleotide synthesis, methylation and reductive
metabolism, and these pathways support the high proliferative rate of cancer cells. As such …

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

Advances in metabolomics have deepened our understanding of the roles that specific
modes of metabolism play in programming stem cell fates. Here, we review recent …

Highlights•Cellular metabolism is 'reprogrammed'to support tumorigenesis.•Amino acids
fulfill many metabolic requirements of proliferating cells.•Specific metabolic pathways can be …

Folate metabolism functions to supply one-carbon units that are vital for a range of
biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units …

Cancer-related metabolism has recently emerged as one of the “hallmarks of cancer”. It has
several important features, including altered metabolism of glucose and glutamine …

Lung cancer is the most common cancer worldwide, accounting for 1.8 million new cases
and 1.6 million deaths in 2012. Non-small cell lung cancer (NSCLC), which is one of two …