Pathophysiology and immunological profile of myasthenia gravis and its subgroups

F Romi, Y Hong, NE Gilhus - Current opinion in immunology, 2017 - Elsevier
Highlights•Myasthenia gravis is an antibody-mediated disease.•Antibodies in myasthenia
gravis are directed against several postsynaptic neuromuscular proteins and …

Thymic germinal centers and corticosteroids in myasthenia gravis: an immunopathological study in 1035 cases and a critical review

F Truffault, V De Montpreville, B Eymard… - Clinical reviews in …, 2017 - Springer
The most common form of Myasthenia gravis (MG) is due to anti-acetylcholine receptor
(AChR) antibodies and is frequently associated with thymic pathology. In this review, we …

Dysregulation of B cell repertoire formation in myasthenia gravis patients revealed through deep sequencing

JA Vander Heiden, P Stathopoulos… - The Journal of …, 2017 - journals.aai.org
Myasthenia gravis (MG) is a prototypical B cell-mediated autoimmune disease affecting 20–
50 people per 100,000. The majority of patients fall into two clinically distinguishable types …

Pediatric myasthenia gravis

JH Peragallo - Seminars in Pediatric Neurology, 2017 - Elsevier
Myasthenia gravis is a disorder of neuromuscular transmission that leads to fatigue of
skeletal muscles and fluctuating weakness. Myasthenia that affects children can be …

Myasthenia gravis: new developments in research and treatment

A Evoli - Current opinion in neurology, 2017 - journals.lww.com
Myasthenia gravis: new developments in research and treatmen... : Current Opinion in
Neurology Myasthenia gravis: new developments in research and treatment : Current …

Multiple antibody detection in 'seronegative'myasthenia gravis patients

Y Hong, P Zisimopoulou, N Trakas… - European journal of …, 2017 - Wiley Online Library
Background and purpose Myasthenia gravis (MG) is an autoimmune disease caused by
antibody mediated impairment in the neuromuscular junction. Seronegative MG (SNMG) …

Screening for lipoprotein receptor-related protein 4-, agrin-, and titin-antibodies and exploring the autoimmune spectrum in myasthenia gravis

I Cordts, N Bodart, K Hartmann, K Karagiorgou… - Journal of …, 2017 - Springer
In autoimmune myasthenia gravis (MG), the identification of antibodies and characterization
of serological subgroups is of great importance for diagnosis and management of the …

Pattern of ocular involvement in myasthenia gravis with MuSK antibodies

A Evoli, PE Alboini, R Iorio, V Damato… - Journal of Neurology …, 2017 - jnnp.bmj.com
Background Myasthenia gravis (MG) with antibodies to the muscle-specific kinase (MuSK)
has a characteristic phenotype. Ocular manifestations have not been systematically …

Anti‐LRP4 autoantibodies in Chinese patients with myasthenia gravis

Y Li, Y Zhang, G Cai, D He, Q Dai, Z Xu… - Muscle & nerve, 2017 - Wiley Online Library
Introduction We assessed antibodies against low‐density lipoprotein receptor‐related
protein 4 (LRP4‐Ab) in a Chinese population with myasthenia gravis (MG). Methods Serum …

[HTML][HTML] Immunization of mice with LRP4 induces myasthenia similar to MuSK-associated myasthenia gravis

S Mori, N Motohashi, R Takashima, M Kishi… - Experimental …, 2017 - Elsevier
Since the first report of experimental animal models of myasthenia gravis (MG) with
autoantibodies against low-density lipoprotein receptor-related protein 4 (LRP4), there have …