Differential requirements for Src-family kinases in SYK or ZAP70-mediated SLP-76 phosphorylation in lymphocytes

F Fasbender, M Claus, S Wingert, M Sandusky… - Frontiers in …, 2017 - frontiersin.org
In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly
phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing …

Modulation of BCR signaling by the induced dimerization of receptor-associated SYK

ML Westbroek, RL Geahlen - Antibodies, 2017 - mdpi.com
Clustering of the B cell antigen receptor (BCR) by polyvalent antigens is transmitted through
the SYK tyrosine kinase to the activation of multiple intracellular pathways that determine the …