Connexins in cardiovascular and neurovascular health and disease: pharmacological implications
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders
B Liu, AG Teschemacher, S Kasparov - Glia, 2017 - Wiley Online Library
Astrocytes are key homeostatic cells of the central nervous system. They cooperate with
neurons at several levels, including ion and water homeostasis, chemical signal …
neurons at several levels, including ion and water homeostasis, chemical signal …
Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea
SL Johnson, F Ceriani, O Houston… - Journal of …, 2017 - Soc Neuroscience
Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin
30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and …
30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and …
Systemic administration of connexin43 mimetic peptide improves functional recovery after traumatic spinal cord injury in adult rats
Y Mao, RS Tonkin, T Nguyen, SJ O'Carroll… - Journal of …, 2017 - liebertpub.com
Blocking of Connexin43 hemichannels, the main gap junction protein located on astrocytes
in the central nervous system, has been shown to reduce neural injury in a number of …
in the central nervous system, has been shown to reduce neural injury in a number of …
Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex
P Bazzigaluppi, I Weisspapir, B Stefanovic… - Neurobiology of …, 2017 - Elsevier
Abstract Extracellular potassium concentration,[K+] o, is a major determinant of neuronal
excitability. In the healthy brain,[K+] o levels are tightly controlled. During seizures,[K+] o …
excitability. In the healthy brain,[K+] o levels are tightly controlled. During seizures,[K+] o …
Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats
Y Mao, T Nguyen, RS Tonkin, JG Lees… - Experimental brain …, 2017 - Springer
Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to
reduce secondary tissue damage and improve functional recovery after spinal cord injury …
reduce secondary tissue damage and improve functional recovery after spinal cord injury …
Systemic administration of a Connexin43 mimetic peptide: a treatment option for spinal cord injury
Y Mao - 2017 - opus.lib.uts.edu.au
Spinal cord injury (SCI) is a major cause of morbidity, and leads to significant physical,
emotional and financial burdens for individuals and their families. There is no known cure to …
emotional and financial burdens for individuals and their families. There is no known cure to …