A hierarchical causal taxonomy of psychopathology across the life span.
We propose a taxonomy of psychopathology based on patterns of shared causal influences
identified in a review of multivariate behavior genetic studies that distinguish genetic and …
identified in a review of multivariate behavior genetic studies that distinguish genetic and …
[HTML][HTML] Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?
The brain and the immune system are not fully formed at birth, but rather continue to mature
in response to the postnatal environment. The two-way interaction between the brain and …
in response to the postnatal environment. The two-way interaction between the brain and …
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
Schizophrenia and the neurodevelopmental continuum: evidence from genomics
MJ Owen, MC O'Donovan - World Psychiatry, 2017 - Wiley Online Library
The idea that disturbances occurring early in brain development contribute to the
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …
Hidden wounds? Inflammatory links between childhood trauma and psychopathology
A Danese, JR Baldwin - Annual review of psychology, 2017 - annualreviews.org
Childhood trauma is a key risk factor for psychopathology. However, little is known about
how exposure to childhood trauma is translated into biological risk for psychopathology …
how exposure to childhood trauma is translated into biological risk for psychopathology …
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
By performing a meta-analysis of rare coding variants in whole-exome sequences from
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and …
[HTML][HTML] Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Borderline personality disorder (BOR) is determined by environmental and genetic factors,
and characterized by affective instability and impulsivity, diagnostic symptoms also observed …
and characterized by affective instability and impulsivity, diagnostic symptoms also observed …
[HTML][HTML] Post-mortem molecular profiling of three psychiatric disorders
Background Psychiatric disorders are multigenic diseases with complex etiology that
contribute significantly to human morbidity and mortality. Although clinically distinct, several …
contribute significantly to human morbidity and mortality. Although clinically distinct, several …
Addressing reverse inference in psychiatric neuroimaging: Meta‐analyses of task‐related brain activation in common mental disorders
E Sprooten, A Rasgon, M Goodman… - Human brain …, 2017 - Wiley Online Library
Functional magnetic resonance imaging (fMRI) studies in psychiatry use various tasks to
identify case‐control differences in the patterns of task‐related brain activation. Differently …
identify case‐control differences in the patterns of task‐related brain activation. Differently …
Psychosis: an autoimmune disease?
Psychotic disorders are common and disabling. Overlaps in clinical course in addition to
epidemiological and genetic associations raise the possibility that autoimmune mechanisms …
epidemiological and genetic associations raise the possibility that autoimmune mechanisms …