The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

An updated systematic review and meta-analysis for treatment of multidrug-resistant tuberculosis

ML Bastos, Z Lan, D Menzies - European Respiratory Journal, 2017 - Eur Respiratory Soc
This systematic review aimed to update the current evidence for multidrug-resistant
tuberculosis (MDR-TB) treatment. We searched for studies that reported treatment …

World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update

D Falzon, HJ Schünemann, E Harausz… - European …, 2017 - Eur Respiratory Soc
Antimicrobial resistance is a major global concern. Tuberculosis (TB) strains resistant to
rifampicin and other TB medicines challenge patient survival and public health. The World …

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

P Miotto, B Tessema, E Tagliani… - European …, 2017 - Eur Respiratory Soc
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium
tuberculosis is required to accelerate the development of rapid drug susceptibility testing …

Long-term outcome and safety of prolonged bedaquiline treatment for multidrug-resistant tuberculosis

L Guglielmetti, M Jaspard, D Le Dû… - European …, 2017 - Eur Respiratory Soc
Bedaquiline, a recently approved drug for the treatment of multidrug-resistant tuberculosis
(MDR-TB), is recommended for a duration of 24 weeks. There are scarce data on patients …

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420

N Blondiaux, M Moune, M Desroses, R Frita, M Flipo… - Science, 2017 - science.org
Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly,
multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now …

Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis

Q Liu, W Li, M Xue, Y Chen, X Du, C Wang, L Han… - Scientific reports, 2017 - nature.com
The high prevalence of diabetes mellitus (DM) among multidrug resistant tuberculosis (MDR-
TB) patients is a serious cause for concern. We conducted a meta-analysis to determine …

[HTML][HTML] Classifying new anti-tuberculosis drugs: rationale and future perspectives

S Tiberi, A Scardigli, R Centis, L D'Ambrosio… - International Journal of …, 2017 - Elsevier
The classification of anti-tuberculosis (TB) drugs is important as it helps the clinician to build
an appropriate anti-TB regimen for multidrug-resistant (MDR) and extensively drug-resistant …

Effectiveness and safety of standardised shorter regimens for multidrug-resistant tuberculosis: individual patient data and aggregate data meta-analyses

FA Khan, MAH Salim, P du Cros… - European …, 2017 - Eur Respiratory Soc
We assessed the effectiveness and safety of standardised, shorter multidrug-resistant
tuberculosis (MDR-TB) regimens by pooling data from observational studies. Published …

S2k-Leitlinie: Tuberkulose im Erwachsenenalter

T Schaberg, T Bauer, F Brinkmann, R Diel… - …, 2017 - thieme-connect.com
In Deutschland ist seit 2015 ein deutlicher Anstieg der gemeldeten Tuberkulosefälle zu
verzeichnen. Zurückzuführen ist dieser vor allem auf die aktuell vermehrte Migration. Durch …