Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for
harnessing the potential of a patient's own immune system to eliminate tumor cells in …

Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

Efficient viral gene expression is threatened by cellular stress response programmes that
rapidly reprioritize the translation machinery in response to varied environmental assaults …

Severe acute respiratory syndrome (SARS) is a respiratory disease, caused by a
coronavirus (SARS-CoV), that is characterized by atypical pneumonia. The nucleocapsid …

Tumors thrive in an immunosuppressive microenvironment that impedes antitumor innate
and adaptive immune responses. Thus, approaches that can overcome immunosuppression …

Antiviral transcriptional responses and regulated cell death are crucial components of the
host response to virus infection. However, in contrast to the signaling pathways that promote …

The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which
include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin …

Mitochondrial antiviral-signaling protein (MAVS) transmits signals from RIG-I-like receptors
after RNA virus infections. However, the mechanism by which MAVS activates downstream …

Type I interferons (IFNs) play a central role in the immune defense against viral infections.
Type I IFN activation is induced by pattern-recognition receptors of the innate immune …

Protective immune responses to viral infection are initiated by innate immune sensors that
survey extracellular and intracellular space for foreign nucleic acids. The existence of these …