Hypoxia inducible factor (HIF) transcription factors are crucial for regulating a variety of
cellular activities in response to oxygen stress (hypoxia). In this study, we determine the …

Classical swine fever (CSF) is one of the most important infectious diseases causing
significant economic losses. Its causal agent, CSF virus (CSFV), is a member of the …

Abstract Background Earthworms (Crassiclitellata) are a diverse group of annelids of
substantial ecological and economic importance. Earthworms are primarily terrestrial …

WUSCHEL-related homeobox (WOX) family is one of the largest group of transcription
factors (TFs) specifically found in plant kingdom. WOX TFs play an important role in plant …

As animals evolved to use oxygen as the main strategy to produce ATP through the process
of mitochondrial oxidative phosphorylation, the ability to adapt to fluctuating oxygen …

Abstract Structure and functional similarities of a recent protein's orthologs with its ancient
counterpart are largely determined by the configuration of evolutionary preservation of …

The digestive tract of lepidopteran insects is unique given its highly alkaline pH. The
adaptive plasticity of digestive enzymes in this environment is crucial to the highly-efficient …

Background Despite extensive study on hemoglobins and hemocyanins, little is known
about hemerythrin (Hr) evolutionary history. Four subgroups of Hrs have been documented …

The plant SABATH gene family is a group of O-methyltransferases (O-MTs), which belongs
to the S-adenosyl-l-methionine-dependent methyltransferases (SAM-MTs). The resulting …

The nuclear-encoded DAG-like (DAL) gene family plays critical roles in organelle C-to-U
RNA editing in Arabidopsis thaliana. However, the origin, diversification and functional …