Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: A virtual screening perspective for the treatment of obesity and diabetes

H Rasouli, SMB Hosseini-Ghazvini, H Adibi… - Food & function, 2017 - pubs.rsc.org
Recently, due to their biological properties, polyphenol-rich functional foods have been
proposed to be unique supplementary and nutraceutical treatments for diabetes mellitus …

Molecular interaction of 2, 4-diacetylphloroglucinol (DAPG) with human serum albumin (HSA): the spectroscopic, calorimetric and computational investigation

M Mondal, K Ramadas, S Natarajan - Spectrochimica Acta Part A …, 2017 - Elsevier
Drug molecule interaction with human serum albumin (HSA) affects the distribution and
elimination of the drug. The compound, 2, 4-diacetylphloroglucinol (DAPG) has been known …

Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L.

EB Kuk, AR Jo, SI Oh, HS Sohn, SH Seong… - Archives of pharmacal …, 2017 - Springer
The inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site
amyloid precursor protein cleaving enzyme 1 (BACE1) plays important roles in prevention …

Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of …

A Kuppusamy, M Arumugam, S George - International journal of biological …, 2017 - Elsevier
The current objective of the study is to identify inhibitory affinity potential of the certain
commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) …

BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium

SH Seong, MY Ali, HR Kim, HA Jung, JS Choi - Bioorganic & medicinal …, 2017 - Elsevier
A wide range of pharmacological properties of Sargassum spp. extracts and isolated
components have been recognized. Although individual meroterpenoids of Sargassum …

Probing the interaction of cephalosporin antibiotic–ceftazidime with human serum albumin: A biophysical investigation

MK Siddiqi, P Alam, SK Chaturvedi, S Nusrat… - International journal of …, 2017 - Elsevier
The fate of drug administered to a living organism depends on drug's pharmacokinetics as
well as pharmacological behavior. Serum albumins (proteins in blood plasma of human) act …

Inhibition study of red rice polyphenols on pancreatic α-amylase activity by kinetic analysis and molecular docking

M Liu, B Hu, H Zhang, Y Zhang, L Wang, H Qian… - Journal of Cereal …, 2017 - Elsevier
This study sought to investigate the possible inhibition mechanism of red rice polyphenols
(RRP) on pancreatic α-amylase (PA) activity. RRP showed strong inhibition against PA …

DFT/B3LYP calculations, in vitro cytotoxicity and antioxidant activities of steroidal pyrimidines and their interaction with HSA using molecular docking and …

A Ali, M Asif, P Alam, MJ Alam, MA Sherwani… - Bioorganic …, 2017 - Elsevier
As a part of our continuing program on the synthesis of steroidal heterocycles, it has been
prepared a series of novel steroidal pyrimidine derivatives 4–6 via TMSCl, steroidal ketones …

Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C‐terminal Domains

MA AlAmri, H Kadri, LJ Alderwick, NS Simpkins… - …, 2017 - Wiley Online Library
SPAK and OSR1 are two protein kinases that have emerged as attractive targets in the
discovery of novel antihypertensive agents due to their role in regulating electrolyte balance …

Targeting of AMP-activated protein kinase: prospects for computer-aided drug design

J Kim, G Yang, J Ha - Expert Opinion on Drug Discovery, 2017 - Taylor & Francis
Introduction: Dysregulation of energy homeostasis has been implicated in a number of
human chronic diseases including diabetes, obesity, cancer, and inflammation. Given the …