Estrogens and androgens in skeletal physiology and pathophysiology
M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
[HTML][HTML] Mechanical basis of bone strength: influence of bone material, bone structure and muscle action
This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and …
J Zheng, AM Erzurumluoglu, BL Elsworth… - …, 2017 - academic.oup.com
Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of …
association study (GWAS) summary-level results data to estimate the SNP heritability of …
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
Wnt signaling and cellular metabolism in osteoblasts
The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …
The determinants of peak bone mass
CM Gordon, BS Zemel, TAL Wren, MB Leonard… - The Journal of …, 2017 - jpeds.com
Osteoporosis poses a significant health burden for the elderly. Although the medical
community recognizes the considerable impact of this disease in adulthood, many primary …
community recognizes the considerable impact of this disease in adulthood, many primary …
[HTML][HTML] Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
MC Zillikens, S Demissie, YH Hsu… - Nature …, 2017 - nature.com
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We
performed a genome-wide association study for whole body (20 cohorts of European …
performed a genome-wide association study for whole body (20 cohorts of European …
Osteoporosis: fracture epidemiology update 2016
JA Cauley - Current opinion in rheumatology, 2017 - journals.lww.com
The purpose of this review is to provide an update on osteoporosis epidemiology. The focus
is on fractures because fractures are the most important clinical consequence of …
is on fractures because fractures are the most important clinical consequence of …
[HTML][HTML] Molecular genetics and targeted therapy of WNT-related human diseases
M Katoh, M Katoh - International journal of …, 2017 - build.spandidos-publications.com
Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …