Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

In this review, we summarize current knowledge regarding the epigenetics of age-related
diseases, focusing on those studies that have described DNA methylation landscape in …

Abstract Purpose of Review Bone remodeling is a diverse field of study with many direct
clinical applications; past studies have implicated epigenetic alterations as key factors of …

Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …

ABSTRACT DNA methylation affects expression of associated genes and may contribute to
the missing genetic effects from genome-wide association studies of osteoporosis. To …

Genetic and environmental determinants of skeletal phenotypes such as bone mineral
density (BMD) may converge through the epigenome, providing a tool to better understand …

Osteoarthritis is a common, complex disease with no curative therapy. In this review, we
summarize current knowledge on disease aetiopathogenesis and outline genetics and …

Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later
life, a relationship that may in part be mediated through altered epigenetic regulation of …

The aim of this study is to identify osteoarthritis (OA)-associated differentially methylated
genes in human articular chondrocytes from patients with OA. DNA methylation profiling of …

Identification of changes in epigenetically regulated control mechanisms in joint tissues has
provided novel insight into underlying mechanism of ongoing osteoarthritis disease …