Mitochondria, known for more than a century as the energy powerhouse of a cell, represent
key intracellular signaling hub that are emerging as important determinants of several …

Cardiovascular diseases are among the leading causes of death worldwide. Reactive
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

Epithelial-to-mesenchymal transition (EMT) allows epithelial cancer cells to assume
mesenchymal features, endowing them with enhanced motility and invasiveness, thus …

Eukaryotes carry numerous asexual cytoplasmic genomes (mitochondria and plastids).
Lacking recombination, asexual genomes should theoretically suffer from impaired adaptive …

Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly
innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring …

Mitochondrial DNA copy number is strictly regulated during development as naive cells
differentiate into mature cells to ensure that specific cell types have sufficient copies of …

The view that genes are constrained within somatic cells is challenged by in vitro evidence,
and more recently by in vivo studies which demonstrate that mitochondria with their …

Mitochondrial DNA (mtDNA), the discrete genome which encodes subunits of the
mitochondrial respiratory chain, is present at highly variable copy numbers across cell types …

Purpose Evidence suggests that mitochondrial DNA (mtDNA) copy number increases in
response to DNA damage. Increased mtDNA copy number has been observed in prostate …